Left Ventricular Systolic Function in Long-Term Survivors Treated as Children, Adolescents, and Young Adults With Allo-HSCT
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) survivors were found to have significantly reduced left ventricular systolic function with echocardiography compared with healthy control subjects. Most cases were described as mild to moderate global hypokinesis with few cases of valve disease. Significant independent predictors of left ventricular systolic function were age, anthracyclines, graft versus host disease, heart rate, and hypertension. 2D = 2-dimensional; 3D = 3-dimensional; LVEF = left ventricular ejection fraction; GLS = global longitudinal strain; MAPSE = mitral annular plane systolic excursion.