Prediction of Lifetime and 10-Year Risk of Cancer in Individual Patients With Established Cardiovascular Disease
Cilie C. van ’t Klooster, Paul M. Ridker, Nancy R. Cook, Joachim G.J.V. Aerts, Jan Westerink, Folkert W. Asselbergs, Yolanda van der Graaf, Frank L.J. Visseren and on behalf of the UCC-SMART Study Group
Prediction of Cancer Risk in Patients With Established Cardiovascular Disease
Using data from the UCC-SMART (Utrecht Cardiovascular Cohort–Second Manifestations of ARTerial disease) cohort, 3 lifetime, competing risk-adjusted prediction models were developed to predict the risk of total, colorectal, and lung cancer with easily clinically available predictors in patients with established cardiovascular disease. Models were externally validated in the CANTOS (Canakinumab Anti-Inflammatory Thrombosis Outcomes Study) data. The models allow for 10-year and lifetime risk predictions. CRP = C-reactive protein; IQR = interquartile range.