Ticagrelor Reduces Platelet Activation in a Cancer Microenvironment
(Left) Summary of the effect of antiplatelets in an in vitro model of platelet−tumor cell interaction within the circulation. Although ticagrelor inhibited aggregation and platelet membrane flipping in both cancer models, there was a lack of effect of ticagrelor or aspirin on breast tumor cell adhesion. In contrast, both drugs were effective in inhibition of colorectal cancer cell adhesion. Neither drug inhibited platelet degranulation. Ticagrelor effects shown in red, aspirin effects in green, − represents drug inhibition, + indicates enhanced activity, x represents no drug effect. (Right) Flowchart of the TICONC (Ticagrelor-Oncology) clinical trial, and levels of activation in circulating platelets isolated from patients with metastatic cancer before commencing antiplatelet therapy. BC = breast cancer; CRC = colorectal cancer; CTC = circulating tumor cells.